In 2019, Blogs & Editorials

Researchers show improvements in knee mobility


BRADENTON, FL – Annie Eng, CEO of HP Ingredients has announced the publication of a new study showing that ParActin® (a patented extract of Andrographis paniculata) confers benefits in those with knee joint discomfort.


The study, “A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis,” led by world-renowned A. paniculata expert Juan Hancke, PhD, was published in Phytotherapy Research 2019; 1-11.


The study examined the efficacy of doses of 300 and 600 mg ParActin® or placebo daily for 84 days on Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores of pain reduction in 103 adults with mild to moderate osteoarthritis of the knee. Parameters tested were joint stiffness, changes in the SF-36 quality of life questionnaire, physical function and fatigue scale.


Among the study findings, the WOMAC pain scores showed a significant and progressive reduction in both ParActin® groups starting at day 28 compared to placebo. The reduction in pain scores from baseline to day 84 within the groups was also highly statistically significant in both ParActin® groups but not in the placebo group. Additionally, the stiffness score was significantly reduced in the ParActin® group by day 84 while there was no improvement in this area in the placebo group. In the quality of life scores, ParActin® groups showed highly significant improvements in physical function score, bodily pain score, and social function score.  In addition, markers of fatigue improved in the ParActin® group.1


The researchers concluded, “Overall, our study is the first clinical placebo-controlled trial that supports a potential use of ParActin® in knee OA patients. We propose that ParActin® can decrease the pain and discomfort of knee osteoarthritis and improve the patient’s general condition and quality of daily life, with no major adverse events.”


This newest study adds to the significant and growing body of research showing ParActin’s efficacy in supporting joint health as well as its unique and potent mechanisms of action. Recent studies showed that Andrographolide inhibited cartilage matrix-degrading enzymes.2 In addition, Andrographolide protects chondrocytes from oxidative stress injury by increasing antioxidant enzyme activity via the activation of the Keap1–Nrf2–Are signaling pathway.  This in vitro study showed that andrographolide increases both catalase and superoxide dismutase in treated chondrocytes, exerting chondroprotective effects, which may slow down the progression of OA.3


Eng noted that while ParActin®-containing products cannot make the disease claims, the results of this study support its use for joint protection formulas. “ParActin® has a solid body of evidence showing its ability to regulate a healthy inflammatory response, and high inflammation is a key characteristic of knee discomfort. This study shows ParActin® has value for keeping people moving and active with less restriction.”


Please visit for the full ParActin® story.



About HP Ingredients

Our portfolio features patented LJ100®-men’s health & sports nutrition; ParActin® -bone, joint health & muscle health; Bergamonte® -metabolic syndrome, cholesterol, blood glucose balance, & weight management; MaquiCare™ – Patagonian superfruit with the highest antioxidant level of all fruits; CitruSlim® – healthy weight management; NeuroActin® – improves learning & memory, helps support neuronal health; NoMax® – increases nitric oxide for enhanced physical performance; QuantumIQ™ – cognitive function, mood, IQ performance; Animal Health: to reduce the use of antibiotics, chemicals, and other pharmaceutical drugs in our food production NatControl™ reduces antibiotic need in salmon for human consumption and SeaControl™ HP Ingredients’ specialized services include custom product development and private labeling of cutting-edge dietary supplements.



1 Hancke, et al. “A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographic paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis.” Phytotherapy Research 2019; 1-11.


2  Tanguenyong, et al. “Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukein-1-beta-induced MMP-2 Expression in Equine Chondrocyte Culture”  International Scholarly Research Notices 2014;


3  Li, et al. “Andrographolide protects chondrocytes from oxidative stress  injury by activation of the Keap1–Nrf2–Are signaling pathway” J Cellular Physiology 2018  DOI: 10.1002/jcp.26769


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